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ADVANCED CARE

Skin Renewal & Repair

Exfoliate, renew, and restore for smoother, healthier-looking skin.

Clinically inspired exfoliation and repair for visibly smoother skin.

Explore the Collection
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    ADVANCED CARE

    Skin Renewal & Repair

    Exfoliate, renew, and restore for smoother, healthier-looking skin.

    Clinically inspired exfoliation and repair for visibly smoother skin.

    Explore the Collection

Best Sellers

    About ZO® Skin Health

    At ZO® Skin Health, we believe the ideal way to attain and maintain skin health is through the power of science. Drawing inspiration from our founder, world-renowned dermatologist Dr. Zein Obagi, ZO® Skin Health continues to push the boundaries of medical-grade skincare.

    Combining our distinct perspective on skin health science with proprietary technologies and product education and protocols, ZO® elevates and optimizes the relationship between skin and skin care.

    We provide comprehensive solutions for maintaining skin at its healthiest – regardless of age, ethnicity, skin condition or skin type. From correcting sun damage and pigmentation to protecting against future damage, ZO® offers a wide spectrum of advanced skincare protocols and products designed to promote healthier skin day after day.

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    The Inventor of Skin Health Science

    Zein Obagi, MD - Researcher. Innovator. Author. Educator.

    • World-renowned dermatologist
    • Founder and medical director of ZO Skin Health, Inc.
    • Author, Obagi Skin Health Restoration & Rejuvenation (1999) and The Art of Skin Health Restoration & Rejuvenation: The Science of Clinical Practice (2015)

    Learn More About Dr. Obagi

    For over 35 years, Dr. Zein Obagi has pioneered advanced skincare solutions based on his philosophy of facilitating healthy skin through science. Rather than merely treating disease and damage, Dr. Obagi’s visionary approach has earned him an international reputation as a leading authority on skin health and rejuvenation. He is ranked among the world’s top experts on chemical peels and treatment of conditions specific to skin of color.

    Inspired by the legacy + breakthrough contributions of Dr. Obagi, ZO® Skin Health continues to redefine and advance the science of skin health.

    Leading Innovation

    ZO® Skin Health’s proprietary innovations include cutting-edge products and treatment protocols that support your skin health. We take pride in developing exceptional skincare solutions that harness the best in skin health science based on proprietary technologies, unique delivery systems, bioengineered complexes and advanced, medical-grade formulations.

    The ZO® method is structured around a three-step approach to skin health.

    Step 1: Getting Skin Ready

    The initial Getting Skin Ready® (GSR®)protocol consists of cleansing, exfoliating and toning. GSR® is the first step to prevent skin aging and bring skin back to its most healthy, balanced state.

    Step 2: Prevent + Correct

    Our Prevent and Correct protocols address your specific skin concerns with ZO® medical-grade treatments and proprietary technologies. Find products to address premature aging, brightening, hydration and more.

    Step 3: Protect

    The Protect step is based on ZO’s Triple-Spectrum Protection® technology that goes beyond conventional sunscreens with scientifically superior, total skin defense.

    Clinically Proven Brightening Care

    Formulated to visibly brighten uneven skin tone while strengthening the skin barrier.

    Powered by advanced vitamin C and multi-pathway brightening technology for a clearer, more radiant complexion.

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      Clinical Proof

      ZO® Skin Health is one of a select few professional skin care lines with a broad range of medical grade skincare comprising advanced skincare protocols and products that prevent aging and offer exceptional skin protection from environmental damage. ZO’s therapeutic treatment protocols and highly effective targeted skin care solutions help reinforce and maintain optimal skin health. Based on the latest scientific advances in skin therapy technologies, our products and protocols help physicians provide continuous skin health care for all skin types, genders and ages.

    Skincare Product Innovation

    At ZO® Skin Health, we believe that the only way to achieve optimal skin health is through the power of science. Founded by world-renowned dermatologist Dr. Zein Obagi, we push the boundaries of medical grade skincare by providing the most innovative skincare products powered by cutting-edge formulas and technologies. Our products and protocols are clinically recognized for their exceptional efficacy as some of the best skin care for aging skin – suitable for maintaining skin health for anyone, regardless of age, ethnicity, unique skin condition or skin type.

    Proprietary Technologies

    ZO® Skin Health’s technological expertise sets us apart. Our proprietary technologies are core to the development of formulations that achieve superior outcomes. ZO®technologies are multi-modal, allowing for the most comprehensive approach to skin health, and are always paired with a delivery system that enables greater penetration and precision. From skin firming ZCORE™ to complete skin protection with Triple- Spectrum Protection™ and our award-winning retinol skin brightener formulations, our products and protocols address the most serious skin concerns at every stage of life.

      Research + Development

      ZO® Skin Health’s Research and Development team focuses on finding unique ingredients that work synergistically to deliver innovative products that our physicians and patients expect from a medical grade skincare brand. Through a combination of professional collaborations, higher education partnerships and unrivaled technical expertise, our R&D team continues to deliver exceptional industry-leading products and protocols for patent-worthy results.

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      Clinical Studies

      ZO® Skin Health’s extensive clinical studies demonstrate the exceptional efficacy of the ZO® Skin Health portfolio of products and protocols. Capturing real results from real patients, our scientific analyses demonstrate our ongoing commitment to the ZO®philosophy that skin health can and should be supported by science.

      • Power Defense

        Hydration

        Daily Power Defense is clinically proven to improve skin hydration and support long-lasting moisture retention.

        Redness / Irritation

        Daily Power Defense helps reinforce the skin’s protective barrier, reducing visible irritation associated with environmental stress.

        Texture & Smoothness

        In clinical testing, participants experienced improved skin texture and a smoother skin surface with regular use.

        Antioxidant Protection

        Daily Power Defense provides daily antioxidant support to help protect against free radical damage and environmental aggressors.

      • Firming Serum

        Elasticity

        Firming Serum is clinically proven to visibly improve skin’s elasticity.

        88% elasticity improvement was measured at 12 weeks.

        Firmness

        Firming Serum is clinically proven to improve the appearance of firmness.

        97% of participants showed significant improvement in skin firmness by week 12.

        Sagging

        Firming Serum is clinically proven to improve the appearance of sagging skin.

        93% of participants showed significant improvement in the appearance of both mid-face and jawline skin sagging by week 12.

      • Wrinkle + Texture Repair

        Hydration

        Wrinkle + Texture Repair is clinically proven to improve the skin’s ability to retain hydration.

        Lines + Wrinkles

        Wrinkle + Texture Repair is clinically proven to improve the appearance of lines and wrinkles.

        98% of participants showed improvement in the appearance of crow’s feet and facial fine lines by week 12.

        Texture

        Wrinkle + Texture Repair is clinically proven to improve the appearance of smooth texture.

        93% of participants showed improvement in skin texture by week 12.
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        Healthy Skin Starts With the Basics

        Getting Skin Ready® (GSR®) is the essential first step to bring skin back to its healthiest state. This simple ZO® Skin Health protocol of cleansing, exfoliating and toning works synergistically to promote skin health restoration and to optimize the effectiveness of our more advanced prevent and correct products, programs and protocols. The GSR® protocol is designed to:

        • Remove surface oil, makeup + pollutants that can cause breakouts and contribute to premature skin aging
        • Initiate renewal of skin’s upper layers to improve texture
        • Enhance penetration of corrective products to optimize overall results
        • Improve microcirculation for a healthier-appearing complexion

        Clinically Proven Results

        At the 8-week interval of a clinical study, patients self-assessed the efficacy of GSR®, reporting statistical improvements across all benefits measured.

        62% improvement in DULLNESS

        69% improvement in OILINESS

        60% improvement in REDNESS

        73% improvement in ROUGHNESS

        PROTOCOL: An 8-week clinical study on 35 subjects. Subjects cleansed AM + PM with Gentle Cleanser, exfoliated in the AM with Exfoliating Polish and toned skin AM + PM with Oil Control Pads. Subjects used their own self-selected SPF 30+ sunscreen during the study.

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        Customer Reviews

        FAQs

        Can I use these products together in the same routine?

        Yes. These formulas are designed to complement each other when used in the correct order. Start with cleansing, follow with exfoliation (if used), then apply treatment products, and finish with your daytime protection.

        Suggested order: Cleanse → Exfoliate → Treat → Protect

        re these products suitable for sensitive skin?

        Most skin types can use these products, but if you have sensitive skin or you’re new to active skincare, introduce one product at a time and increase frequency gradually. If irritation occurs, reduce usage and focus on barrier support.

        When should I expect to see results?

        Results vary by skin type and consistency. Many users notice improved smoothness and hydration within 1–2 weeks. Visible improvements in tone, texture, and overall skin quality typically appear within 4–8 weeks, with best results over 12 weeks of consistent use.

        Should I use these in the morning or at night?

        It depends on the product and your skin’s tolerance. Daily antioxidant and barrier-support products are typically used in the morning, while exfoliating and retinol-based products are often best used at night. Always follow the directions on each product and adjust frequency as needed.

        What should I avoid while using active skincare?

        Avoid over-exfoliating and introducing too many actives at once. Wear sunscreen daily, especially when using exfoliating or retinol products. If you experience dryness, stinging, or excessive redness, scale back and reintroduce gradually.